Formyl Peptide Receptor-Like 1 Antagonist; WRW4

Code: 344220-5MG D2-231

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetFormyl Peptide Receptor-Like 1 (FPRL1)

Targ...


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Your Price
€502.10 EACH
€617.58 inc. VAT

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetFormyl Peptide Receptor-Like 1 (FPRL1)

Target IC50: 230 nM for FPRL1 Agonist

General description

A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with the ligand-receptor interaction {IC50 = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks the ligand activated [Ca2+]i increase, ERK activation and chemotactic migration of FPRL1-expressing RBL-2H3 cells at 10 µM. Further, inhibits Aβ42 peptide-induced superoxide generation and prevents its internalization in human macrophages.

A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with ligand-receptor interaction {IC50 = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks ligand-mediated [Ca2+]i increase, ERK activation, and chemotactic migration of FPRL1-expressing RBL-2H3 cells at a concentration of 10 µM. Also inhibits Aβ42 peptide-induced superoxide generation and prevents its internalization in human macrophages.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Bae, Y.S., et al. 2004. J. Immunol.173, 607.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Sequence

H-Trp-Arg-Trp-Trp-Trp-Trp-CONH₂

Warning

Toxicity: Standard Handling (A)

assay≥95% (HPLC)
colorwhite
formlyophilized solid
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inambient
solubilityDMSO: 5 mg/mL
storage conditiondesiccated (hygroscopic), OK to freeze
storage temp.2-8°C
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