Biochem/physiol Actions
Cell permeable: no
Reversible: no
Product does not compete with ATP.
Primary TargetFormyl Peptide Receptor-Like 1 (FPRL1)
Target IC50: 230 nM for FPRL1 Agonist
General description
A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with the ligand-receptor interaction {IC50 = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks the ligand activated [Ca2+]i increase, ERK activation and chemotactic migration of FPRL1-expressing RBL-2H3 cells at 10 µM. Further, inhibits Aβ42 peptide-induced superoxide generation and prevents its internalization in human macrophages.
A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with ligand-receptor interaction {IC50 = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks ligand-mediated [Ca2+]i increase, ERK activation, and chemotactic migration of FPRL1-expressing RBL-2H3 cells at a concentration of 10 µM. Also inhibits Aβ42 peptide-induced superoxide generation and prevents its internalization in human macrophages.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Bae, Y.S., et al. 2004. J. Immunol.173, 607.
Packaging
Packaged under inert gas
5 mg in Plastic ampoule
Physical form
Supplied as a trifluoroacetate salt.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Sequence
H-Trp-Arg-Trp-Trp-Trp-Trp-CONH₂
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria to qualify for the following awards: